BioSimulators & Services

A New Approach to Research

We offer a revolutionary approach to preclincial research, bringing your device from concept to real-world applications without the need for in-vivo animal models. We offer 3 ways to engage, R&D in our lab facility, lease in your facility, or full technology purchase.

We offer multiple ways to engage with our BioSimulation equipment. Partner with us for R&D in our laboratory, lease or purchase equipment for your facility, or work with us on comprehensive training on the equipment itself or for training clinical providers.

Explore Our Comprehensive Suite of BioSimulators

Cardiac BioSimulator

Visualize Device Delivery & Deployment in a Pressurized Heart

Our Cardiac BioSimulator is the ideal platform for visualizing cardiovascular device delivery and conducting training sessions. This innovative system connects a cadaveric heart to a pulsatile fluid circulation, simulating venous and arterial pressures using an external pump to generate cardiac output. Unlike PhysioHeart™, where the heart itself acts as the pump, the Cardiac BioSimulator uses precise computer-controlled stroke volume to actuate the heart.

With customizable vascular add-ons, this platform supports a variety of delivery pathways, including trans-apical, trans-aortic, venous, and trans-septal methods. The realistic hydrodynamics and heart wall movement allow for a detailed assessment of device functionality, implantability, and operability. Visualize every step with real-time endoscopic video, providing intuitive views of your device’s interaction with the heart’s internal structures. Whether assessing prototype devices or instructing new clinical users, this platform offers unmatched visual feedback.

Compatible with a range of clinical imaging technologies—such as 3D ultrasound, fluoroscopy, CT, and MRI—the Cardiac BioSimulator provides an extensive array of visualization tools, allowing for a comprehensive study and training experience.

PhysioHeart™

Experience Real-Time Cardiac Testing with PhysioHeart

PhysioHeart™ is an ex-vivo, isolated, autonomously beating heart model, designed to replicate the true performance of a living heart. This advanced platform showcases cardiac muscle contraction, hemodynamic activity, realistic heart valve movement, and electrophysiological responses. It offers an unparalleled environment for testing the functionality and feasibility of surgical and interventional devices, providing precise insights into performance.

Unlike animal models, PhysioHeart™ allows for real-time imaging via ultrasound, CT, or MR, enabling full visual assessment during your procedures. Our expertise combined with this dynamic model, gives you a unique opportunity to enhance device development and streamline your processes in a realistic cardiac setting, for faster iterations and dramatic cost savings.

VAscular BIOreactor

Advanced Vascular Bioreactor for Long-Term Vessel Culture

VABIO (Vascular BIOreactor) bridges the gap between non-physiological in-vitro studies and costly in-vivo animal studies. This innovative platform enables long-term ex-vivo culture of isolated blood vessels under controlled flow and pressure, closely mimicking physiological conditions. With features like automatic medium exchange and blood-like medium for enhanced tissue viability, VABIO surpasses traditional in-vitro setups.

Fully autoclavable and accessible, VABIO allows catheter-based device introduction, simulating interventions and enabling intravascular imaging. It’s ideal for testing devices, therapies, and pharmaceuticals, accelerating research while reducing costs.

BioLiver

Advanced Ex-Vivo Liver Model for Hepatic Research

The BioLiver Platform provides a highly realistic ex-vivo liver model, featuring physiological blood flows, intact cell structure, and a functional gall bladder. Designed to assess the acute effects of hepatic devices and therapies, BioLiver offers visual, hemodynamic, histological, and metabolic evaluations in one experiment—something not easily achievable in biopsies or in-vivo studies.

With its complex cell structure intact and perfusion control, BioLiver allows for comprehensive testing of liver devices, therapies, and metabolism under real-life conditions, reducing the need for animal studies. Compatible with imaging and continuous monitoring, it’s ideal for research, training, and device validation. With the support of our expert team, we can help design your experiment and provide answers to any questions you may have, ensuring your research runs smoothly and effectively.

Heart Valve Assessment

Precision Testing for Prosthetic Valves

Our Heart Valve Assessment platform offers customizable pulse duplicator testing for prosthetic valves and aortic devices. Standard regulatory testing focuses on reproducible results in a controlled environment, but true valve performance relies on realistic conditions. Our platform replicates in-vivo dynamics, ensuring your valve is tested under relevant preclinical conditions, tailored to your product’s unique characteristics.

Capable of testing heart valves of various sizes and positions, our LifeTec platform provides validated hydrodynamic performance and durability testing according to ISO standards. With high-speed imaging and modular, customizable setups, we recreate anatomical features and support clinical imaging. Our experienced team provides expert guidance throughout design and preclinical stages, helping you refine your product early and reduce risks. Paired with our Cardiac BioSimulator or PhysioHeart platforms, you have the complete solution for valve testing and user training.

We offer a suite of advanced simulators designed to streamline and improve your R&D along with:

Fully supported preclinical R&D studies as a service
Access to our BioSimulation technologies through leasing or purchase
Hands-on clinical training and workshops in realistic environments to train your end-users
Explore Real-World Applications

Discover our extensive collection of case studies and publications showcasing real-world results and insights.

Our Team is Your Team

Our Team is Your Team

Collaboration Through & Through.

Collaborative research

A Resolution Medical supported experiment is the easiest way to access our BioSimulator systems. We’ll work closely with your team to plan and configure the setup, while our engineers operate the simulators, allowing you to focus on your device or procedure.

Experiments can be conducted at our labs in Eindhoven, Minneapolis, or at your preferred location.

We collaborate with you at any stage of the lifecycle, providing expert guidance every step of the way. Discover how we can support you below.

Concept & Product Development

Support the technical development of a project from conception to first-in-human clinical study through a formal iterative process with experienced engineers.

BioSimulation & Testing

Iterate and train under one roof. Gain unmatched visualization of cardiovascular device delivery and deployment in a pressurized heart with fully realistic function in a cath lab setting.

New Product Introduction (NPI)

Structured transfer process of devices into manufacturing including design for manufacturing, process development, supplier optimization, and verification and validation testing activities.

Medical Device Manufacturing

Broad, end-to-end manufacturing that supports small runs through commercial production. Specialized clean rooms, sterile packaging and labeling, distribution, and more.